Artificial intelligence shows potential for accurate assessment of nailfold changes in systemic sclerosis patients

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, showed that the Vision Transformer, an open-source computer vision algorithm, could detect changes in nailfold capillaroscopy images from systemic sclerosis patients, as reliably as human rheumatologists. Systemic sclerosis (SSc, scleroderma) is a rare connective tissue disease marked by tightening […]

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Study links lower hydroxychloroquine dose to more hospitalizations for systemic lupus erythematosus flares

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual scientific meeting, found that the recommended weight-based or non-weight-based dose of hydroxychloroquine led to more hospitalizations for flares among patients with systemic lupus erythematosus. Hydroxychloroquine (HCQ), the mainstay treatment for systemic lupus erythematosus (SLE), reduces flares and improves long-term outcomes. […]

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Study finds combination therapy does little to slow spine damage in radiographic axial spondyloarthritis patients

New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, showed that combining a nonsteroidal anti-inflammatory drug and TNF inhibitor did not significantly slow radiographic spinal progression in radiographic axial spondyloarthritis patients. Axial spondyloarthritis (axSpA) is a chronic inflammatory condition with two subsets: non-radiographic axial spondyloarthritis and radiographic axial […]

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Predictive molecular biomarkers for determining neoadjuvant chemosensitivity in muscle invasive bladder cancer

A new research paper was published in Oncotarget entitled “Predictive molecular biomarkers for determining neoadjuvant chemosensitivity in muscle invasive bladder cancer.” Identifying neoadjuvant chemotherapy (NAC) response in patients with muscle invasive bladder cancer (MIBC) has had limited success based on clinicopathological features and molecular subtyping. Identification of chemotherapy responsive cohorts would facilitate delivery to those […]

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Accelerating the development of effective psychological interventions

Researchers at Ruhr University Bochum, Germany, have started investigating whether there might be faster and more efficient ways to develop and improve mental health interventions. In the journal Psychological Medicine, they present the “leapfrog design” as a means to efficiently test new interventions without having to conduct several clinical trials one after the other. “Clinical […]

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Scientists get clearer picture of developing teen brain

In a paper published in Progress in Neurobiology, University of Pittsburgh School of Medicine neuroscientists described compelling new evidence of a critical neuroplasticity period in the frontal brain region during adolescence, a time when major mental illnesses such as depression and schizophrenia emerge and risk-taking behavior peaks. Using more than double the resolution of typical […]

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